Article
Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative.
Cancer discovery - 1 Nov 2021
Aftimos Philippe, Oliveira Mafalda, Irrthum Alexandre, Fumagalli Debora, Sotiriou Christos, Gal-Yam Einav Nili, Robson Mark E, Ndozeng Justin, Di Leo Angelo, Ciruelos Eva M, de Azambuja Evandro, Viale Giuseppe, Scheepers Elsemieke D, Curigliano Giuseppe, Bliss Judith M, Reis-Filho Jorge S, Colleoni Marco, Balic Marija, Cardoso Fatima, Albanell Joan, Duhem Caroline, Marreaud Sandrine, Romagnoli Dario, Rojas Beatriz, Gombos Andrea, Wildiers Hans, Guerrero-Zotano Angel, Hall Peter, Bonetti Andrea, Larsson Karolina Fs, Degiorgis Martina, Khodaverdi Silvia, Greil Richard, Sverrisdóttir Ásgerdur, Paoli Marta, Seyll Ethel, Loibl Sibylle, Linderholm Barbro, Zoppoli Gabriele, Davidson Nancy E, Johannsson Oskar Th, Bedard Philippe L, Loi Sherene, Knox Susan, Cameron David A, Harbeck Nadia, Montoya Maite Lasa, Brandão Mariana, Vingiani Andrea, Caballero Carmela, Hilbers Florentine S, Yates Lucy R, Benelli Matteo, Venet David, Piccart Martine J
Abstract excerpt
AURORA aims to study the processes of relapse in metastatic breast cancer (MBC) by performing multi-omics profiling on paired primary tumors and early-course metastases. Among 381 patients (primary tumor and metastasis pairs: 252 targeted gene sequencing, 152 RNA sequencing, 67 single nucleotide polymorphism arrays), we found a driver role for GATA1 and MEN1 somatic mutations. Metastases were enriched in ESR1,...
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