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Article

Analysis of KRAS, NRAS, PIK3CA, and BRAF mutational profile in poorly differentiated clusters of KRAS-mutated colon cancer.

Human pathology - 1 Apr 2017

Reggiani Bonetti Luca, Barresi Valeria, Bettelli Stefania, Caprera Cecilia, Manfredini Samantha, Maiorana Antonio

Abstract excerpt

Recently, a grading system based on the counting of poorly differentiated clusters (PDCs) of neoplastic cells was shown to be a strong predictor of nodal metastases and negative prognosis in colon cancer (CC). In this study, we assessed and compared the mutational status of KRAS, NRAS, and PIK3CA in PDCs and corresponding main tumor tissue of 25 CCs with KRAS mutations. For each tumor, PDC and main tumor tissue...

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Source

Identifiers

PMID: 28025078
DOI: 10.1016/j.humpath.2016.12.011

Genes

KRAS
NRAS
PDC
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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