Article
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jun 2012
Mannan Abdul, Hahn-Strömberg Victoria
Abstract excerpt
In colorectal carcinoma, pathological assessment of tumors is essential for determining therapy and prognosis of the disease. Molecular associations of tumor complexity index and genetic alternations can be helpful to understand the tumor progression mechanism. Oncogenic K-ras is one of the major colorectal cancer associated genes, and is mutated in up to 50% of colorectal cancers. In this current study, we...
Topics
- Adult
- Aged
- Aged, 80 and over
- Colonic Neoplasms
- Female
- Genes, ras
- Humans
- Lymph Nodes
- Lymphatic Metastasis
- Male
- Middle Aged
- Mutation