Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KRAS, NRAS, BRAF mutations and high counts of poorly differentiated clusters of neoplastic cells in colorectal cancer: observational analysis of 175 cases.

Pathology - 1 Oct 2015

Barresi Valeria, Bonetti Luca Reggiani, Bettelli Stefania

Abstract excerpt

A novel grading system based on the counting of poorly differentiated clusters (PDC) of neoplastic cells at the invasive margin and in the tumour stroma was recently introduced among the histological parameters predictive of adverse clinical outcome in colorectal cancer (CRC). The aim of this study was to correlate the histological grade based on PDC and the mutational status of KRAS, NRAS and BRAF genes in 175...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to GTP Phosphohydrolases

Share to Multiplex Polymerase Chain Reaction

Share to Neoplasm Grading

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 26352110
DOI: 10.1097/PAT.0000000000000300

Genes

PDC
KRAS
BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KRAS, NRAS, BRAF mutations and high counts of poorly differentiated clusters of neoplastic cells in colorectal cancer: observational analysis of 175 cases.PMID 26352110Read ↗

Analysis of KRAS, NRAS, PIK3CA, and BRAF mutational profile in poorly differentiated clusters of KRAS-mutated colon cancer.Semantic proximity Read ↗

The prognostic significance of growth pattern, tumor budding, poorly differentiated clusters, desmoplastic reaction pattern and tumor-stroma ratio in colorectal cancer and an evaluation of their relationship with KRAS, NRAS, BRAF mutations.Semantic proximity Read ↗

Assessing the applicability and interobserver variability of tumor budding and poorly differentiated clusters in colorectal cancerSemantic proximity Read ↗

Prognostic Biomarkers of Cell Proliferation in Colorectal Cancer (CRC): From Immunohistochemistry to Molecular Biology TechniquesSemantic proximity Read ↗

Novel applications of histopathological markers to distinguish prognostic subgroups in colorectal adenocarcinoma.Semantic proximity Read ↗

Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system.Semantic proximity Read ↗

KRAS/NRAS Mutations Associated with Distant Metastasis and BRAF/PIK3CA Mutations Associated with Poor Tumor Differentiation in Colorectal CancerSemantic proximity Read ↗

The Good, the Bad and the Ugly - Novel Synoptic Variables in the Personalisation of Colon Cancer TreatmentSemantic proximity Read ↗

Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology–molecular associations: clinical and biological implicationsSemantic proximity Read ↗

Clinicopathological and genetic differences between low-grade and high-grade colorectal mucinous adenocarcinomas.Semantic proximity Read ↗

Distinct molecular features of different macroscopic subtypes of colorectal neoplasms.Semantic proximity Read ↗

Clinicopathologic distribution of KRAS and BRAF mutations in a Chinese population with colorectal cancer precursor lesions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.