Article
Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers.
International journal of cancer - 15 May 2008
Barault Ludovic, Veyrie Nicolas, Jooste Valerie, Lecorre Delphine, Chapusot Caroline, Ferraz Jean-Marc, Lièvre Astrid, Cortet Marion, Bouvier Anne-Marie, Rat Patrick, Roignot Patrick, Faivre Jean, Laurent-Puig Pierre, Piard Francoise
Abstract excerpt
The RAS-MAPK, PI (3)K signaling pathways form a network that play a central role in tumorigenesis. The BRAF, KRAS and PI3KCA genes code 3 partners of this network and have been found to be activated by mutation in colorectal cancer; these mutations lead to unrestricted cell growth. We evaluated the clinicopathological features and the prognosis of patients with activated-network colon cancers in a...
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