Article
Tumor phosphatidylinositol-3-kinase signaling and development of metastatic disease in locally advanced rectal cancer.
PloS one - 1 Jan 2012
Ree Anne Hansen, Kristensen Annette Torgunrud, Saelen Marie Grøn, de Wijn Rik, Edvardsen Hege, Jovanovic Jovana, Abrahamsen Torveig Weum, Dueland Svein, Flatmark Kjersti
Abstract excerpt
BACKGROUND: Recognizing EGFR as key orchestrator of the metastatic process in colorectal cancer, but also the substantial heterogeneity of responses to anti-EGFR therapy, we examined the pattern of composite tumor kinase activities governed by EGFR-mediated signaling that might be implicated in development of metastatic disease. PATIENTS AND METHODS: Point mutations in KRAS, BRAF, and PIK3CA and ERBB2...
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