Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel NHERF1 Mutation in Human Breast Cancer and Effects on Malignant Progression.

Anticancer research - 1 Jan 2017

Yang Xiaomei, Du Guifang, Yu Zhen, Si Yang, Martin Tracey A, He Junqi, Cheng Shan, Jiang Wen G

Abstract excerpt

Na+/H+ exchanger regulatory factor 1 (NHERF1) has been reported to interact with post-synaptic density protein/Drosophila disc large tumour suppressor/zonula occludens 1 protein (PDZ) binding proteins by its two PDZ domains. These associations have effects on cellular signal transductions. NHERF1 has also been indicated as a cancer-related gene in several solid tumour types. We identified a novel mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COS Cells

Share to MCF-7 Cells

Share to Neoplasm Invasiveness

Share to Protein Interaction Domains and Motifs

Share to Sodium-Hydrogen Exchangers

Share to YAP-Signaling Proteins

Source

Identifiers

PMID: 28011475
DOI: 10.21873/anticanres.11290

Genes

NHERF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

A Novel NHERF1 Mutation in Human Breast Cancer and Effects on Malignant Progression.PMID 28011475Read ↗

The cellular distribution of Na+/H+ exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer.Semantic proximity Read ↗

A Novel NHERF1 Mutation in Human Breast Cancer Inactivates Inhibition by NHERF1 Protein in EGFR Signaling.Semantic proximity Read ↗

The prognostic value of the Na+/H+ exchanger regulatory factor 1 (NHERF1) protein in cancerSemantic proximity Read ↗

Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling.Semantic proximity Read ↗

Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1)Semantic proximity Read ↗

NHERF (Na+/H+ exchanger regulatory factor) gene mutations in human breast cancer.Semantic proximity Read ↗

Inside Out: Targeting NHE1 as an Intracellular and Extracellular Regulator of Cancer ProgressionSemantic proximity Read ↗

A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.Semantic proximity Read ↗

MUC1 regulates nuclear localization and function of the epidermal growth factor receptorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.