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Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1)

1 Nov 2006

Abstract excerpt

INTRODUCTION: Na+/H+ exchanger regulatory factor 1 (NHERF1, also known as EBP50 or NHERF) is a putative tumour suppressor gene in human breast cancer. Located at 17q25.1, NHERF1 is frequently targeted during breast tumourigenesis. Loss of heterozygosity (LOH) at the NHERF1 locus is found in more than 50% of breast tumours. In addition, NHERF1 is mutated in a subset of primary breast tumours and breast cancer cell...

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PMID: 17078868
DOI: 10.1186/bcr1616

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