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Article

A Novel NHERF1 Mutation in Human Breast Cancer Inactivates Inhibition by NHERF1 Protein in EGFR Signaling.

Anticancer research - 1 Mar 2016

DU Guifang, Hao Chengcheng, Gu Yanan, Wang Zhiyan, Jiang Wen G, He Junqi, Cheng Shan

Abstract excerpt

BACKGROUND: Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) has been reported to interact with many cancer-related proteins. We recently identified a novel NHERF1 mutation (E43G) in breast tumours. MATERIALS AND METHODS: The candidates of NHERF1 mutation were identified in breast cancer tissues by polymerase chain reaction and DNA sequencing. Wild-type NHERF1 and E43G mutation were expressed in NHERF1-knockdown...

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Identifiers

PMID: 26977012

Genes

NHERF1
EGFR
EGF

Variants

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