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Article

MUC1 regulates nuclear localization and function of the epidermal growth factor receptor

21 Apr 2010

Abstract excerpt

Alteration of protein trafficking and localization is associated with several diseases, including cystic fibrosis, breast cancer, colorectal cancer, leukemia and diabetes. Specifically, aberrant nuclear localization of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is a poor prognostic indicator in several epithelial carcinomas. It is now appreciated that in addition to signaling from...

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PMID: 20406885
DOI: 10.1242/jcs.062661

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