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Article

Inside Out: Targeting NHE1 as an Intracellular and Extracellular Regulator of Cancer Progression

17 Dec 2012

Abstract excerpt

The sodium hydrogen exchanger isoform one is a critical regulator of intracellular pH, serves as an anchor for the formation of cytoplasmic signaling complexes, and modulates cytoskeletal organization. There is a growing interest in the potential for sodium hydrogen exchanger isoform one as a therapeutic target against cancer. Sodium hydrogen exchanger isoform one transport drives formation of membrane...

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PMID: 23253131
DOI: 10.1111/cbdd.12035

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