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Article

Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling.

FEBS letters - 11 Oct 2013

Cheng Shan, Li Yang, Yang Ying, Feng Duiping, Yang Longyan, Ma Qian, Zheng Shuai, Meng Ran, Wang Shuhui, Wang Songlin, Jiang Wen G, He Junqi

Abstract excerpt

Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) is a scaffold protein known to interact with a number of cancer-related proteins. nherf1 Mutations (K172N and D301V) were recently identified in breast cancer cells. To investigate the functional properties of NHERF1, wild-type and cancer-derived nherf1 mutations were stably expressed in SKMES-1 cells respectively. NHERF1-wt overexpression suppressed the cellular...

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Identifiers

PMID: 24012959
DOI: 10.1016/j.febslet.2013.08.026

Genes

NHERF1
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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