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Article

The cellular distribution of Na+/H+ exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer.

Oncotarget - 17 May 2016

Du Guifang, Gu Yanan, Hao Chengcheng, Yuan Zhu, He Junqi, Jiang Wen G, Cheng Shan

Abstract excerpt

The oncogenic role of ectopic expression of Na+/H+ exchanger regulatory factor 1 (NHERF1) was recently suggested. Here, we show that NHERF1 was upregulated in high grades compared with low grades. Increased NHERF1 expression was correlated with poor prognosis and poor survival. NHERF1 expression was higher in the nucleus of cancer cells than in contiguous non- mammary epithelial cells. A novel mutation, namely...

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Source

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Identifiers

PMID: 27097111
DOI: 10.18632/oncotarget.8751
PMCID: PMC5045408

Genes

NHERF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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