Cdx2 is essential for axial elongation in mouse development.

doi:10.1073/pnas.0401654101

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Article

Cdx2 is essential for axial elongation in mouse development.

Proceedings of the National Academy of Sciences of the United States of America - 18 May 2004

Chawengsaksophak Kallayanee, de Graaff Wim, Rossant Janet, Deschamps Jacqueline, Beck Felix

Abstract excerpt

Inactivation of Cdx2 leads to preimplantation embryonic lethality. Rescue of the implantation defect by tetraploid fusion established that Cdx2 is necessary for trophoblastic development, vasculogenesis in the yolk sac mesoderm, allantoic growth, and chorioallantoic fusion. "Rescued" Cdx2 mutants die at late gastrulation stages because of failure of placental development. Cdx2 is also needed for the completion of...

Topics

Animals
Blastocyst
Body Patterning
CDX2 Transcription Factor
Ectoderm
Endoderm
Gastrula
Gene Expression Regulation, Developmental
Genes, Homeobox
Homeodomain Proteins
Mesoderm
Mice
Phenotype
Polyploidy
Stem Cells
Transcription Factors
Trophoblasts

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Identifiers

PMID: 15136723
DOI: 10.1073/pnas.0401654101
PMCID: PMC419659

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