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Article

Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling.

Scientific reports - 19 Dec 2016

Ma Min, Ren Qian, Yang Chun, Zhang Ji-Chun, Yao Wei, Dong Chao, Ohgi Yuta, Futamura Takashi, Hashimoto Kenji

Abstract excerpt

Addition of low doses of the atypical antipsychotic drug brexpiprazole with selective serotonin reuptake inhibitors (SSRIs) could promote antidepressant effect in patients with major depressive disorder although the precise mechanisms underlying the action of the combination are unknown. Combination of low dose of brexpiprazole (0.1 mg/kg) and SSRI fluoxetine (10 mg/kg) could promote a rapid antidepressant effect...

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Identifiers

PMID: 27991542
DOI: 10.1038/srep39209
PMCID: PMC5171769

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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