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Article

2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.

International journal of molecular sciences - 30 Nov 2020

Lee Young-Ju, Kim Hye Ryeong, Lee Chang Youn, Hyun Sung-Ae, Ko Moon Yi, Lee Byoung-Seok, Hwang Dae Youn, Ka Minhan

Abstract excerpt

Depression is a serious medical illness that is one of the most prevalent psychiatric disorders. Corticosterone (CORT) increases depression-like behavior, with some effects on anxiety-like behavior. 2-Phenethylamine (PEA) is a monoamine alkaloid that acts as a central nervous system stimulant in humans. Here, we show that PEA exerts antidepressant effects by modulating the Brain-derived neurotrophic factor...

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Identifiers

PMID: 33265983
DOI: 10.3390/ijms21239103
PMCID: PMC7729630

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