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Article

Depression-like phenotype following chronic CB1 receptor antagonism.

Neurobiology of disease - 1 Aug 2010

Beyer Chad E, Dwyer Jason M, Piesla Michael J, Platt Brian J, Shen Ru, Rahman Zia, Chan Karen, Manners Melissa T, Samad Tarek A, Kennedy Jeffrey D, Bingham Brendan, Whiteside Garth T

Abstract excerpt

Rimonabant was the first clinically marketed cannabinoid (CB)(1) receptor antagonist developed to treat obesity. Unfortunately, CB(1) receptor antagonism produced adverse psychiatric events in patients. To determine whether this occurs pre-clinically, we investigated the effects of rimonabant in rodent models of mood disorders. Chronic treatment with rimonabant increased immobility time in the rat forced swim...

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Identifiers

PMID: 20381618
DOI: 10.1016/j.nbd.2010.03.020

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BDNF
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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