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Article

Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1crv4 mouse model of SCAR13 ataxia.

Neurobiology of disease - 1 Jan 2018

Bossi Simone, Musante Ilaria, Bonfiglio Tommaso, Bonifacino Tiziana, Emionite Laura, Cerminara Maria, Cervetto Chiara, Marcoli Manuela, Bonanno Giambattista, Ravazzolo Roberto, Pittaluga Anna, Puliti Aldamaria

Abstract excerpt

Deleterious mutations in the glutamate receptor metabotropic 1 gene (GRM1) cause a recessive form of cerebellar ataxia, SCAR13. GRM1 and GRM5 code for the metabotropic glutamate type 1 (mGlu1) and type 5 (mGlu5) receptors, respectively. Their different expression profiles suggest they could have distinct functional roles. In a previous study, homozygous mice lacking mGlu1 receptors (Grm1crv4/crv4) and exhibiting...

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Identifiers

PMID: 28982591
DOI: 10.1016/j.nbd.2017.10.001

Genes

GRM1
GRM5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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