Article
Compensatory molecular and functional mechanisms in nervous system of the Grm1(crv4) mouse lacking the mGlu1 receptor: a model for motor coordination deficits.
Cerebral cortex (New York, N.Y. : 1991) - 1 Sept 2013
Rossi Pia Irene Anna, Musante Ilaria, Summa Maria, Pittaluga Anna, Emionite Laura, Ikehata Masami, Rastaldi Maria Pia, Ravazzolo Roberto, Puliti Aldamaria
Abstract excerpt
The metabotropic glutamate type 1 (mGlu1) and type 5 (mGlu5) receptors, the only members of group I mGlu receptors, are implicated in synaptic plasticity and mechanisms of feedback control of glutamate release. They exhibit nearly complementary distributions throughout the central nervous system, well evident in the cerebellum, where mGlu1 receptor is most intensely expressed while mGlu5 receptor is not. Despite...
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