Article
Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2003
Leheste Jörg R, Melsen Flemming, Wellner Maren, Jansen Pernille, Schlichting Uwe, Renner-Müller Ingrid, Andreassen Troels T, Wolf Eckehard, Bachmann Sebastian, Nykjaer Anders, Willnow Thomas E
Abstract excerpt
Megalin is an endocytic receptor highly expressed in the proximal tubules of the kidney. Recently, we demonstrated that this receptor is essential for the renal uptake and conversion of 25-OH vitamin D3 to 1,25-(OH)2 vitamin D3, a central step in vitamin D and bone metabolism. Unfortunately, the perinatal lethality of the conventional megalin knockout mouse model precluded the detailed analysis of the...
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