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Article

Isolation and characterization of a novel human scFv inhibiting EGFR vIII expressing cancers.

Immunology letters - 1 Dec 2016

Rahbarnia Leila, Farajnia Safar, Babaei Hossein, Majidi Jafar, Dariushnejad Hassan, Hosseini Mohammad Kazem

Abstract excerpt

EGFRvIII, a mutant form of epidermal growth factor receptor is highly expressed in glioblastoma, carcinoma of the breast, ovary, and lung but not in normal cells. This tumor specific antigen has emerged as a promising candidate for antibody based therapy of several cancers. The aim of the present study was isolation and characterization of a human single chain antibody against EGFRvIII as a promising target for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27984065
DOI: 10.1016/j.imlet.2016.10.008

Genes

CDR2
EGFR

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