Article
Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display.
Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 1996
Lorimer I A, Keppler-Hafkemeyer A, Beers R A, Pegram C N, Bigner D D, Pastan I
Abstract excerpt
EGFRvIII is a mutant epidermal growth factor receptor found in glioblastoma, and in carcinoma of the breast, ovary, and lung. The mutant receptor has a deletion in its extracellular domain that results in the formation of a new, tumor-specific extracellular sequence. Mice were immunized with a sy...
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