Article

Elucidating key determinants of engineered scFv antibody in MMP-9 binding using high throughput screening and machine learning

2024-06-06

Abstract excerpt

<h4>ABSTRACT</h4> An imbalance in matrix metalloproteinase-9 (MMP-9) regulation can lead to numerous diseases, including neurological disorders, cancer, and pre-term labor. Engineering single-chain antibody fragments (scFvs) Targeting MMP-9 to develop novel therapeutics for such diseases is desirable. We screened a synthetic scFv antibody library displayed on the yeast surface for binding improvement to MMP-9 usi...

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Literature Corpus work: 1da4f139-8cff-50cb-aafc-1202646e8526
DOI: 10.1101/2024.06.04.597476

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