Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

humMR1, a highly specific humanized single chain antibody for targeting EGFRvIII.

International immunopharmacology - 1 Feb 2014

Safdari Yaghoub, Farajnia Safar, Asgharzadeh Mohammad, Omidfar Kobra, Khalili Masoumeh

Abstract excerpt

Production of an efficient humanized single chain antibody is reported here to specifically target EGFRvIII, a truncated receptor expressed in a wide variety of human cancers. CDR loops of MR1, a phage display-derived murine single chain antibody developed against this mutant receptor, were grafted on human frameworks that had been selected based on similarity to MR1 in terms of two distinct parameters, variable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Line
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Minor Histocompatibility Antigens

Share to Protein Conformation

Share to Sequence Alignment

Share to Single-Chain Antibodies

Source

Identifiers

PMID: 24370392
DOI: 10.1016/j.intimp.2013.12.006

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

humMR1, a highly specific humanized single chain antibody for targeting EGFRvIII.PMID 24370392Read ↗

Isolation and characterization of a novel human scFv inhibiting EGFR vIII expressing cancers.Semantic proximity Read ↗

A universal combinatorial design of antibody framework to graft distinct CDR sequences: a bioinformatics approach.Semantic proximity Read ↗

Development of an Engineered Single-Domain Antibody for Targeting MET in Non-Small Cell Lung CancerSemantic proximity Read ↗

Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent.Semantic proximity Read ↗

Humanization of the anti-CD18 antibody 6.7: an unexpected effect of a framework residue in binding to antigen.Semantic proximity Read ↗

Humanization of Predicted T-Cell Epitopes Reduces the Immunogenicity of Chimeric Antibodies: New Evidence Supporting a Simple MethodSemantic proximity Read ↗

NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodiesSemantic proximity Read ↗

Construction of a large phage-displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain.Semantic proximity Read ↗

A phage display approach for rapid antibody humanization: Designed combinatorial V gene librariesSemantic proximity Read ↗

Generic Approach for the Generation of Stable Humanized Single-chain Fv Fragments from Rabbit Monoclonal AntibodiesSemantic proximity Read ↗

Selection of a PD ‐1 blocking antibody from a novel fully human phage display librarySemantic proximity Read ↗

Structure- and sequence-based design of synthetic single-domain antibody librariesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.