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Article

Δ40p53α suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells.

Journal of cell science - 1 Feb 2017

Ota Akinobu, Nakao Haruhisa, Sawada Yumi, Karnan Sivasundaram, Wahiduzzaman Md, Inoue Tadahisa, Kobayashi Yuji, Yamamoto Takaya, Ishii Norimitsu, Ohashi Tomohiko, Nakade Yukiomi, Sato Ken, Itoh Kiyoaki, Konishi Hiroyuki, Hosokawa Yoshitaka, Yoneda Masashi

Abstract excerpt

Splice variants of certain genes impact on genetic biodiversity in mammals. The tumor suppressor TP53 gene (encoding p53) plays an important role in the regulation of tumorigenesis in hepatocellular carcinoma (HCC). Δ40p53α is a naturally occurring p53 isoform that lacks the N-terminal transactivation domain, yet little is known about the role of Δ40p53α in the development of HCC. Here, we first report on the...

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Identifiers

PMID: 27980070
DOI: 10.1242/jcs.190736
PMCID: PMC5312733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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