Article

p53 isoform expression promotes a stemness phenotype and inhibits doxorubicin sensitivity in breast cancer

2023-03-27

Abstract excerpt

<title>Abstract</title><p>In breast cancer, dysregulated<italic>TP53</italic>expression signatures are a better predictor of chemotherapy response and survival outcomes than<italic>TP53</italic>mutations. Our previous studies have shown that high levels of Δ40p53 are associated with worse disease-free survival and disruption of p53-induced DNA damage response in breast cancers. Here, we further investigated the<it...

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Literature Corpus work: 989413a3-3a5e-53cf-b7ca-6200d73623a0
DOI: 10.21203/rs.3.rs-2536787/v1

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