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Article

p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence.

Nature cell biology - 1 Sept 2009

Fujita Kaori, Mondal Abdul M, Horikawa Izumi, Nguyen Giang H, Kumamoto Kensuke, Sohn Jane J, Bowman Elise D, Mathe Ewy A, Schetter Aaron J, Pine Sharon R, Ji Helen, Vojtesek Borivoj, Bourdon Jean-Christophe, Lane David P, Harris Curtis C

Abstract excerpt

The finite proliferative potential of normal human cells leads to replicative cellular senescence, which is a critical barrier to tumour progression in vivo. We show that the human p53 isoforms Delta133p53 and p53beta function in an endogenous regulatory mechanism for p53-mediated replicative senescence. Induced p53beta and diminished Delta133p53 were associated with replicative senescence, but not...

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Identifiers

PMID: 19701195
DOI: 10.1038/ncb1928
PMCID: PMC2802853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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