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Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage

28 Oct 2022

Abstract excerpt

Our previous studies have shown that p53 isoform expression is altered in breast cancer and related to prognosis. In particular, a high ∆40p53:p53α ratio is associated with worse disease-free survival. In this manuscript, the influence of altered Δ40p53 and p53α levels on the response to standard of care DNA-damaging agents used in breast cancer treatment was investigated in vitro. Our results revealed that a...

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PMID: 36307393
DOI: 10.1038/s41419-022-05349-9

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