Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.

doi:10.1016/S1474-4422(16)30291-5

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Article

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.

The Lancet. Neurology - 1 Jan 2017

Irwin David J, Grossman Murray, Weintraub Daniel, Hurtig Howard I, Duda John E, Xie Sharon X, Lee Edward B, Van Deerlin Vivianna M, Lopez Oscar L, Kofler Julia K, Nelson Peter T, Jicha Gregory A, Woltjer Randy, Quinn Joseph F, Kaye Jeffery, Leverenz James B, Tsuang Debby, Longfellow Katelan, Yearout Dora, Kukull Walter, Keene C Dirk, Montine Thomas J, Zabetian Cyrus P, Trojanowski John Q

Abstract excerpt

BACKGROUND: Great heterogeneity exists in survival and the interval between onset of motor symptoms and dementia symptoms across synucleinopathies. We aimed to identify genetic and pathological markers that have the strongest association with these features of clinical heterogeneity in synucleinopathies. METHODS: In this retrospective study, we examined symptom onset, and genetic and neuropathological data from a...

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PMID: 27979356
DOI: 10.1016/S1474-4422(16)30291-5
PMCID: PMC5181646

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