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Article

The progression of pathology in Parkinson's disease.

Annals of the New York Academy of Sciences - 1 Jan 2010

Halliday Glenda Margaret, McCann Heather

Abstract excerpt

To identify the progression of pathology over the entire course of Parkinson's disease, we longitudinally followed a clinical cohort to autopsy and identified three clinicopathological phenotypes that progress at different rates. Typical Parkinson's disease has an initial rapid loss of midbrain dopamine neurons with a slow progression of Lewy body infiltration into the brain (over decades). Dementia intervenes...

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Identifiers

PMID: 20146698
DOI: 10.1111/j.1749-6632.2009.05118.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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