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Alpha-Synuclein and Cognitive Decline in Parkinson Disease

16 Nov 2021

Abstract excerpt

Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from...

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PMID: 34833115
DOI: 10.3390/life11111239

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