Article
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.
The Lancet. Neurology - 1 Feb 2020
Moore Katrina M, Nicholas Jennifer, Grossman Murray, McMillan Corey T, Irwin David J, Massimo Lauren, Van Deerlin Vivianna M, Warren Jason D, Fox Nick C, Rossor Martin N, Mead Simon, Bocchetta Martina, Boeve Bradley F, Knopman David S, Graff-Radford Neill R, Forsberg Leah K, Rademakers Rosa, Wszolek Zbigniew K, van Swieten John C, Jiskoot Lize C, Meeter Lieke H, Dopper Elise Gp, Papma Janne M, Snowden Julie S, Saxon Jennifer, Jones Matthew, Pickering-Brown Stuart, Le Ber Isabelle, Camuzat Agnès, Brice Alexis, Caroppo Paola, Ghidoni Roberta, Pievani Michela, Benussi Luisa, Binetti Giuliano, Dickerson Bradford C, Lucente Diane, Krivensky Samantha, Graff Caroline, Öijerstedt Linn, Fallström Marie, Thonberg Håkan, Ghoshal Nupur, Morris John C, Borroni Barbara, Benussi Alberto, Padovani Alessandro, Galimberti Daniela, Scarpini Elio, Fumagalli Giorgio G, Mackenzie Ian R, Hsiung Ging-Yuek R, Sengdy Pheth, Boxer Adam L, Rosen Howie, Taylor Joanne B, Synofzik Matthis, Wilke Carlo, Sulzer Patricia, Hodges John R, Halliday Glenda, Kwok John, Sanchez-Valle Raquel, Lladó Albert, Borrego-Ecija Sergi, Santana Isabel, Almeida Maria Rosário, Tábuas-Pereira Miguel, Moreno Fermin, Barandiaran Myriam, Indakoetxea Begoña, Levin Johannes, Danek Adrian, Rowe James B, Cope Thomas E, Otto Markus, Anderl-Straub Sarah, de Mendonça Alexandre, Maruta Carolina, Masellis Mario, Black Sandra E, Couratier Philippe, Lautrette Geraldine, Huey Edward D, Sorbi Sandro, Nacmias Benedetta, Laforce Robert, Tremblay Marie-Pier L, Vandenberghe Rik, Damme Philip Van, Rogalski Emily J, Weintraub Sandra, Gerhard Alexander, Onyike Chiadi U, Ducharme Simon, Papageorgiou Sokratis G, Ng Adeline Su Lyn, Brodtmann Amy, Finger Elizabeth, Guerreiro Rita, Bras Jose, Rohrer Jonathan D
Abstract excerpt
BACKGROUND: Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT,...