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Article

Generation and characterization of mice for conditional inactivation of Zeb1.

Genesis (New York, N.Y. : 2000) - 1 Apr 2017

Brabletz Simone, Lasierra Losada María, Schmalhofer Otto, Mitschke Julia, Krebs Angela, Brabletz Thomas, Stemmler Marc P

Abstract excerpt

The multizinc finger containing transcription factor ZEB1 plays crucial roles during various aspects of mammalian development and tumorigenesis. Best studied in human tumors, ZEB1 is activating the embryo-derived program of epithelial-mesenchymal transition (EMT). The aberrant activation of EMT confers an invasive metastasizing phenotype with acquisition of stem cell properties and resistance to radio- and...

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Source

Identifiers

PMID: 28176446
DOI: 10.1002/dvg.23024

Genes

ZEB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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