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Article

Zeb1 links epithelial-mesenchymal transition and cellular senescence.

Development (Cambridge, England) - 1 Feb 2008

Liu Yongqing, El-Naggar Shahenda, Darling Douglas S, Higashi Yujiro, Dean Douglas C

Abstract excerpt

Overexpression of zinc finger E-box binding homeobox transcription factor 1 (Zeb1) in cancer leads to epithelial-to-mesenchymal transition (EMT) and increased metastasis. As opposed to overexpression, we show that mutation of Zeb1 in mice causes a mesenchymal-epithelial transition in gene expression characterized by ectopic expression of epithelial genes such as E-cadherin and loss of expression of mesenchymal...

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Identifiers

PMID: 18192284
DOI: 10.1242/dev.007047
PMCID: PMC2507753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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