Article
Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region.
Tropical medicine & international health : TM & IH - 1 Aug 2012
Kano Flora S, Sanchez Bruno A M, Sousa Tais N, Tang Michaelis L, Saliba Jéssica, Oliveira Fernando M, Nogueira Paulo A, Gonçalves Alessandra Q, Fontes Cor J F, Soares Irene S, Brito Cristiana F A, Rocha Roberto S, Carvalho Luzia H
Abstract excerpt
OBJECTIVE: To investigate risk factors associated with the acquisition of antibodies against Plasmodium vivax Duffy binding protein (PvDBP) - a leading malaria vaccine candidate - in a well-consolidated agricultural settlement of the Brazilian Amazon Region and to determine the sequence diversity of the PvDBP ligand domain (DBP(II)) within the local malaria parasite population. METHODS: Demographic,...
Topics
- Adolescent
- Adult
- Age Factors
- Antibodies, Protozoan
- Antigens, Protozoan
- Brazil
- Child
- Cross-Sectional Studies
- DNA, Protozoan
- Enzyme-Linked Immunosorbent Assay