Article
Natural acquired inhibitory antibodies to Plasmodium vivax Duffy binding protein (PvDBP-II) equally block erythrocyte binding of homologous and heterologous expressed PvDBP-II on the surface of COS-7 cells.
Medical microbiology and immunology - 1 Feb 2016
Valizadeh Vahideh, Zakeri Sedigheh, Mehrizi Akram A, Mirkazemi Sedigheh, Djadid Navid D
Abstract excerpt
The binding domain of Plasmodium vivax Duffy binding protein (PvDBP-II) is a promising blood-stage vaccine candidate for vivax malaria. For the development of a successful vivax malaria vaccine based on DBP-II, the antigenic diversity and also naturally occurring functional antibodies to different PvDBP-II variant types in the various populations must be determined. However, similar to other blood-stage antigens,...
Topics
- Adolescent
- Adult
- Animals
- Antibodies, Protozoan
- Antigens, Protozoan
- COS Cells
- Cell Adhesion
- Child
- Epithelial Cells
- Erythrocytes