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RNA polymerase modulators and DNA repair activities resolve conflicts between DNA replication and transcription.

Molecular cell - 22 Jul 2005

Trautinger Brigitte W, Jaktaji Razieh P, Rusakova Ekaterina, Lloyd Robert G

Abstract excerpt

Organisms rely on close interplay between DNA replication, recombination, and repair to secure transmission of the genome. In rapidly dividing cells, there is also great pressure for transcription, which may induce conflict with replication. We investigated the potential for conflict in bacterial cells, where there is no temporal separation of these processes. Eliminating the stringent response regulators ppGpp...

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Identifiers

PMID: 16039593
DOI: 10.1016/j.molcel.2005.06.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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