Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear import of Nkx2-2 is mediated by multiple pathways.

Biochemical and biophysical research communications - 22 Jan 2017

Lin Wenbo, Xu PengPeng, Guo YingYing, Jia Qingjie, Tao Tao

Abstract excerpt

Nkx2-2 homeoprotein is essential for the development of the central nervous system and pancreas. Although the nuclear localization signals of Nkx2-2 have been identified, the responsible transport receptor is still unknown. Here, we demonstrate that imp α1 not only interacts with Nkx2-2 but also transports it into the nucleus in vitro by acting together with imp β1. However, the nuclear import of Nkx2-2 in cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to beta Karyopherins
Share to Karyopherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NIH 3T3 Cells

Share to Nuclear Localization Signals

Share to Phosphoric Monoester Hydrolases

Share to RNA, Small Interfering

Share to Zebrafish Proteins

Source

Identifiers

PMID: 27956177
DOI: 10.1016/j.bbrc.2016.12.065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear import of Nkx2-2 is mediated by multiple pathways.PMID 27956177Read ↗

Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.Semantic proximity Read ↗

Heterodimerization of mouse orexin type 2 receptor variants and the effects on signal transduction.Semantic proximity Read ↗

A novel receptor-mediated nuclear protein import pathway.Semantic proximity Read ↗

Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR.Semantic proximity Read ↗

Distinct mutations in importin-β family nucleocytoplasmic transport receptors transportin-SR and importin-13 affect specific cargo binding.Semantic proximity Read ↗

Drosophila Importin-α2 is involved in synapse, axon and muscle development.Semantic proximity Read ↗

Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.Semantic proximity Read ↗

Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import.Semantic proximity Read ↗

Nuclear import of c-Jun is mediated by multiple transport receptors.Semantic proximity Read ↗

Neurotensin-Mediated Activation of MAPK Pathways and AP-1 Binding in the Human Pancreatic Cancer Cell Line, MIA PaCa-2Semantic proximity Read ↗

Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran.Semantic proximity Read ↗

Nuclear localization of bradykinin B(2) receptors reflects binding to the nuclear envelope protein lamin C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.