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Article

Distinct mutations in importin-β family nucleocytoplasmic transport receptors transportin-SR and importin-13 affect specific cargo binding.

Scientific reports - 2 Aug 2021

Kimura Makoto, Imai Kenichiro, Morinaka Yuriko, Hosono-Sakuma Yoshiko, Horton Paul, Imamoto Naoko

Abstract excerpt

Importin-(Imp)β family nucleocytoplasmic transport receptors (NTRs) are supposed to bind to their cargoes through interaction between a confined interface on an NTR and a nuclear localization or export signal (NLS/NES) on a cargo. Although consensus NLS/NES sequence motifs have been defined for cargoes of some NTRs, many experimentally identified cargoes of those NTRs lack those motifs, and consensus NLSs/NESs...

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Identifiers

PMID: 34341383
DOI: 10.1038/s41598-021-94948-1
PMCID: PMC8329185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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