Article
Nuclear localization of bradykinin B(2) receptors reflects binding to the nuclear envelope protein lamin C.
European journal of pharmacology - 15 Jan 2014
Takano Masaoki, Kanoh Akira, Amako Katsumi, Otani Mieko, Sano Keiji, Kanazawa-Hamada Michiko, Matsuyama Shogo
Abstract excerpt
The mechanism of action of bradykinin (BK), a pro-inflammatory mediator, is thought to be mediated by specific cell surface membrane bradykinin B2 receptors. Some evidence suggests that there are both intracellular and nuclear bradykinin B2 receptors. This study identified proteins that interact with the C-terminus of the bradykinin B2 receptor (in particular, the nuclear membrane protein lamin C), using the...
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