Article
Heterodimerization of mouse orexin type 2 receptor variants and the effects on signal transduction.
Biochimica et biophysica acta - 1 Mar 2014
Wang Chunmei, Pan Yanyou, Zhang Rumin, Bai Bo, Chen Jing, Randeva Harpal S
Abstract excerpt
Orexin-A and Orexin-B play important roles in many physiological processes in which Orexins orchestrate diverse downstream effects via two G-protein coupled receptors: Orexin1R and Orexin2R. Two alternative C-terminus splice variants of the mouse Orexin receptors mOX2alphaR and mOX2betaR have recently been identified. This study explored the possibility of heterodimerization between mOX2alphaR and mOX2betaR, and...
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