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Article

Sedative effect of Clozapine is a function of 5-HT2A and environmental novelty.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jan 2017

Joshi Radhika S, Quadros Rolen, Drumm Michael, Ain Rupasri, Panicker Mitradas M

Abstract excerpt

Antipsychotic drugs are the mainstay in the treatment of schizophrenia and bipolar disorder. However, antipsychotics often exhibit sedation or activity suppression among many other side effects, and the factors that influence them remain poorly understood. We now show, using a 5-HT2A knockout (Htr2a-/-) mouse, that environmental circumstances can affect suppression of activity induced by the atypical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27955831
DOI: 10.1016/j.euroneuro.2016.10.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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