Article
5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response.
Behavioural brain research - 29 Jan 2001
Dirks A, Pattij T, Bouwknecht J A, Westphal T T, Hijzen T H, Groenink L, van der Gugten J, Oosting R S, Hen R, Geyer M A, Olivier B
Abstract excerpt
To investigate whether the hyperreactivity to mild environmental and novel stimuli in 5-HT1B receptor knockout (1BKO) mice, as suggested by measures of exploratory, aggressive, and impulsive behaviors, can be extended to phasic stimuli, 1BKO and wildtype mice were tested in acoustic startle reactivity and plasticity paradigms, including habituation, prepulse inhibition, and footshock-induced sensitization of the...
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