ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.

doi:10.1128/MCB.01008-12

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Article

ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.

Molecular and cellular biology - 1 Jan 2013

Chandler Ronald L, Brennan Jennifer, Schisler Jonathan C, Serber Daniel, Patterson Cam, Magnuson Terry

Abstract excerpt

Every known SWI/SNF chromatin-remodeling complex incorporates an ARID DNA binding domain-containing subunit. Despite being a ubiquitous component of the complex, physiological roles for this domain remain undefined. Here, we show that disruption of ARID1a-DNA binding in mice results in embryonic lethality, with mutant embryos manifesting prominent defects in the heart and extraembryonic vasculature. The DNA...

Topics

Alleles
Amino Acid Sequence
Animals
Chromatin
Chromatin Assembly and Disassembly
Computational Biology
DNA
DNA-Binding Proteins
Embryo, Mammalian
Embryonic Stem Cells
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Deletion

Gene Expression Regulation, Developmental

Genotype

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Nuclear Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23129809
DOI: 10.1128/MCB.01008-12
PMCID: PMC3554127

Genes

THBS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23129809-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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