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Article

ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.

Molecular and cellular biology - 1 Jan 2013

Chandler Ronald L, Brennan Jennifer, Schisler Jonathan C, Serber Daniel, Patterson Cam, Magnuson Terry

Abstract excerpt

Every known SWI/SNF chromatin-remodeling complex incorporates an ARID DNA binding domain-containing subunit. Despite being a ubiquitous component of the complex, physiological roles for this domain remain undefined. Here, we show that disruption of ARID1a-DNA binding in mice results in embryonic lethality, with mutant embryos manifesting prominent defects in the heart and extraembryonic vasculature. The DNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23129809
DOI: 10.1128/MCB.01008-12
PMCID: PMC3554127

Genes

THBS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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