Article
Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming.
Nature communications - 1 Jun 2020
Suryo Rahmanto Yohan, Shen Wenjing, Shi Xu, Chen Xi, Yu Yu, Yu Zheng-Cheng, Miyamoto Tsutomu, Lee Meng-Horng, Singh Vivek, Asaka Ryoichi, Shimberg Geoffrey, Vitolo Michele I, Martin Stuart S, Wirtz Denis, Drapkin Ronny, Xuan Jianhua, Wang Tian-Li, Shih Ie-Ming
Abstract excerpt
Somatic inactivating mutations of ARID1A, a SWI/SNF chromatin remodeling gene, are prevalent in human endometrium-related malignancies. To elucidate the mechanisms underlying how ARID1A deleterious mutation contributes to tumorigenesis, we establish genetically engineered murine models with Arid1a and/or Pten conditional deletion in the endometrium. Transcriptomic analyses on endometrial cancers and precursors...
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