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Article

Arid1a is essential for intestinal stem cells through Sox9 regulation

11 Jan 2019

Abstract excerpt

Inactivating mutations of Arid1a , a subunit of the Switch/sucrose nonfermentable chromatin remodeling complex, have been reported in multiple human cancers. Intestinal deletion of Arid1a has been reported to induce colorectal cancer in mice; however, its functional role in intestinal homeostasis remains unclear. We investigated the functional role of Arid1a in intestinal homeostasis in mice. We found that...

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PMID: 30635419
DOI: 10.1073/pnas.1804858116

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