Article
Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states.
Nature genetics - 1 Feb 2017
Kadoch Cigall, Williams Robert T, Calarco Joseph P, Miller Erik L, Weber Christopher M, Braun Simon M G, Pulice John L, Chory Emma J, Crabtree Gerald R
Abstract excerpt
The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF) complexes has a critical role in both development and disease. Mutations in the genes encoding BAF subunits contribute to more than 20% of human malignancies, yet the underlying mechanisms remain unclear, owing largely to a lack of assays to assess BAF function in living cells. To address this, we have developed a widely applicable...
Topics
- Carcinogenesis
- Chromatin
- DNA Replication
- DNA-Binding Proteins
- Epigenesis, Genetic
- Heterochromatin
- Humans
- Mutation
- Nuclear Proteins
- Polycomb-Group Proteins
- RNA Polymerase II