Article
LC-MS/MS Analysis of Erythrocyte Thiopurine Nucleotides and Their Association With Genetic Variants in Patients With Neuromyelitis Optica Spectrum Disorders Taking Azathioprine.
Therapeutic drug monitoring - 1 Feb 2017
Mei Shenghui, Li Xindi, Gong Xiaoqing, Li Xingang, Yang Li, Zhou Heng, Liu Yonghong, Zhou Anna, Zhu Leting, Zhang Xinghu, Zhao Zhigang
Abstract excerpt
BACKGROUND: Azathioprine is a first-line drug in treating neuromyelitis optica spectrum disorders (NMOSD). To exhibit its bioactivity, azathioprine needs to be converted to thiopurine nucleotides (TPNs) including 6-thioguanine nucleotides (6-TGNs) and 6-methylmercaptopurine nucleotides (6-MMPNs) that are affected by genetic polymorphisms. This study aims to develop an LC-MS/MS method for the analysis of...
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