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Article

Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis.

Scientific reports - 12 Apr 2021

Miao Qiang, Yan Lin, Zhou Yanhong, Li Yi, Zou Yuangao, Wang Lanlan, Bai Yangjuan, Zhang Junlong

Abstract excerpt

This study aimed to investigate the influence of TPMT*3C, ITPA, NUDT15, and 6-thioguanine nucleotides (6-TGN) on azathioprine (AZA)-induced myelosuppression in Southwest China patients with autoimmune hepatitis (AIH). A total of 113 Chinese patients with AIH receiving AZA maintenance treatment were evaluated. The relevant clinical data of the patients were collected from the hospital information system....

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Azathioprine
Genetic Association Studies
Guanine Nucleotides
Hepatitis, Autoimmune
Leukopenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methyltransferases

Pyrophosphatases

Thionucleotides

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Identifiers

PMID: 33846471
DOI: 10.1038/s41598-021-87095-0
PMCID: PMC8042108

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Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis.PMID 33846471Read ↗

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