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Influence of TPMT and NUDT15 Genetic Polymorphisms on Mercaptopurine Pharmacokinetics in Healthy Volunteers.

Genetic testing and molecular biomarkers - 1 Aug 2024

Kong Qihui, Zhang Qiqi, Chen Di, Lou Jinfang, Zhu Jian, Chen Mingjing, Li Ting

Abstract excerpt

Aims: This study aimed to investigate the impact of genetic polymorphisms of thiopurine methyltransferase (TPMT) and NUDT15 on pharmacokinetics profile of mercaptopurine in healthy adults in China. Methods: Blood samples were obtained from 45 healthy adult volunteers who were administered azathioprine. Genomic DNA was extracted and sequenced for TPMT and NUDT15. The plasma concentrations of 6-mercaptopurine...

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Asian People
Azathioprine
China
Healthy Volunteers
Mercaptopurine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methyltransferases

Pyrophosphatases

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PMID: 39084859
DOI: 10.1089/gtmb.2023.0605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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